She continued in employment there for over ten years, defending her thesis in 1993 to receive a degree in medical science.

In 2004 she was elected to the Legislative Chamber of Uzbekistan, where she served as a member of the Committee on International Affairs and Interparliamentary Relations.

In 2005 she was elected first secretary of the Justice Social Democratic Party, serving as head of its parliamentary faction.

[1] The party nominated her to run against Islam Karimov in the presidential election of 2007, in which she garnered just under 3% of the vote.

[6] Tashmukhamedova has written a number of articles on subjects related to medicine, politics, and women's rights.