[2] When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to be a mixture of caffeine and lidocaine,[3] and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users.

[7] These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the central nervous system.

[5] Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:[5] cocaine > dimethocaine > tetracaine > procaine > chloroprocaine Furthermore, the administration of dimethocaine has been shown to lead to antinociceptive responses at nontoxic doses in mice.

[9] These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system.

A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.

The main phase I reactions are ester hydrolysis, deethylation, hydroxylation of the aromatic system, or a combination of these three.

These side effects include: tachycardia, difficulty with breathing, pain on the chest, vasoconstriction, insomnia, paranoia and anxiety.

This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.

This test showed induced dose-dependent antinociceptive responses, which are processes that block detection of a painful or injurious stimulus by sensory neurons.

[9] Impairment of memory processes was found to be a toxic effect in the elevated plus-maze test in mice.

[10] Sweden's public health agency suggested classifying Dimethocaine as a hazardous substance, on September 25, 2019.