Dimethoxanate (trade names Cothera, Cotrane, Atuss, Perlatoss, Tossizid)[1] is a cough suppressant of the phenothiazine class.

[2] Dimethoxanate may have analgesic, local anesthetic, and central nervous system depressant effects, but it may also produce nausea and vomiting.

[4] Dimethoxanate was introduced in Austria, Belgium, and France in 1911, and in Italy and Spain in 1963.

[5] Approval for marketing in the US was withdrawn by the FDA in 1975 due to lack of evidence of efficacy.

Further reaction with 2-(2-(dimethylamino)ethoxy)ethanol [1704-62-7] (3) completed the synthesis of Dimethoxanate (4).