SKF-83,959, a synthetic benzazepine derivative used in scientific research, acts as an agonist at the D1–D2 dopamine receptor heteromer.

[1] It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer.

It was further shown to act as an allosteric modulator of the sigma-1 receptor.

[4] SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL-202 and MCL-201, respectively.

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