He has also created multiple animated TV shows such as Moral Orel, Mary Shelley's Frankenhole, and High School USA!.

As an actor, he is best known for his recurring role as the character Alex "Star-Burns" Osbourne on the NBC comedy series Community, on which he also worked as a producer, a consulting writer, and wrote two animated episodes.

[1] Stamatopoulos was hired on The Ben Stiller Show after Andy Dick convinced him to submit a spec script for a Simpsons episode.

Stamatopoulos worked as a creative consultant and contributing writer on the first season of Tom Goes to the Mayor, with Tim & Eric and Bob Odenkirk.

He played the recurring role of Alex "Star-Burns" Osbourne, a character whose nickname derived from his large star-shaped sideburns.