The see is first mentioned in the Council of Ephesus in 431, when Bishop Euprepius held the joint episcopacy of Bizye and Arcadiopolis.
[1][2] Arcadiopolis was originally a suffragan bishop of Heraclea in Europa, metropolitan see and capital of the Roman province of Europa, but became an autocephalous archbishopric by the late ninth century, and eventually a metropolitan see probably during the reign of Isaac II Angelos (r.
Bishop Peter is known from his seal dated to the 9th/10th centuries, and an archbishop John signed the decree against the Jacobites in 1032.
[2] A metropolitan Malachias is attested in April 1329, but following the town's conquest by the Ottoman Turks later in the century the see fell vacant and was abandoned.
[3] Marcel Lefebvre, the founder of the Society of Saint Pius X, was one of its titular bishops.