It was erected on 22 December 2014 by Pope Francis with territory taken from the Diocese of Kottar.

[1][2] For health reasons Bishop Jerome submitted his resignation to Pope Francis which was accepted on 6 June 2020.

Simultaneously, Pope Francis appointed the Metropolitan Archbishop of Madurai, Antony Pappusamy, as Apostolic Administrator of the diocese of Kuzhithura.

[3] Bifurcation of the diocese of Kottar had been a long-standing demand of the people of the region.

[4] Prior to this bifurcation, Kottar diocese had been one of the largest in India with over 500000 Catholics.