The Diocese of San Jose, Nueva Ecija (Latin: Dioecesis Sancti Iosephi in Insulis Philippinis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in the Philippines.

The diocese held its first Diocesan Synod in March 2011 led by the Apostolic Nuncio to the Philippines.

The Diocese of San Jose, Nueva Ecija, was created on Feb. 16, 1984 by Pope John Paul II and canonically erected on July 14, 1984.

Its territory was taken from the Diocese of Cabanatuan which at same time of the division comprised the entire province of Nueva Ecija.

Bishop Leo M. Drona had been a Salesian of Don Bosco for twenty nine-years prior to his episcopal appointment.