[1] In 1516[2]: 186  he was appointed Metropolis of Nicomedia and he was consecrated bishop by Patriarch Theoleptus I of Constantinople.

[1] Dionysius was designed by Patriarch Jeremias I of Constantinople as his successor, and, after Jeremias I's death, he was actually elected on 17 April 1546[2]: 39  supported by popular manifestations and against the hopes of the Holy Synod.

[3] During his Patriarchate he was blamed for having raised the appointment fee (peshtesh) due to the Ottoman Sultan to three thousand Écus and for the demolition, ordered by the Sultan, of the great cross on the roof of the Pammakaristos Church, at the time the seat of the Patriarchate.

In 1548 these news caused a great concern in a part of the Greek population of Constantinople, with riots and an attempt to murder Dionysius II, who was considered as guilty as Metrophanes.

[5] Dionysius II was on the point of being deposed, but no actions were taken against him because he enjoyed the support of Suleiman the Magnificent.