In 2011, he and fellow producer Switch formed the electronic musical group Major Lazer and its namesake cartoon series for FXX,[3] which ran for one season.

Since then, Diplo has produced for and collaborated with a number of mainstream musical acts, including Lil Peep, Gwen Stefani, Die Antwoord, Britney Spears, Madonna, Shakira, Beyoncé, Ellie Goulding, No Doubt, Justin Bieber, Usher, Snoop Dogg, Trippie Redd, Chris Brown, CL, G-Dragon, Bad Bunny, Kali Uchis, Joji, MØ and Poppy.

[7][21] Diplo eschewed the club aesthetic of his Hollertronix music for a more reflective sound on his solo debut, Florida, which was released on the Ninja Tune imprint, Big Dada Records.

Similar to the Florida DVD, "Banned in Libya" is an experimental audio and video mix of some of Diplo's original music blended with a number of other unidentified sources.

[1] It was not long before his Hooked on Hollertronix parties would provide him the success necessary to move to the next logical step and build a studio where music would become his full-time focus.

[24] Since its inception, artists such as Christina Aguilera, Shakira, M.I.A., Santigold, Spank Rock, Plastic Little, Blaqstarr, and Paper Route Gangstaz have recorded at The Mausoleum.

Since its foundation in 2005[35] Diplo's Mad Decent label has released music by Santigold, Baauer, Lil' Jon, Gucci Mane, Peter Bjorn and John, Rusko, Bosco Delrey, Buraka Som Sistema, Savage Skulls, Dana Sibuea, Oliver Twizt, Jamie Fanatic, Douster, Boy 8-Bit, and Popo.

He has produced for artists such as Beyoncé, Justin Bieber, Lil Wayne, Britney Spears, Wale, Chris Brown, Ariana Grande, 2 Chainz, Travis Porter, Usher, Azealia Banks, Iggy Azalea, and AlunaGeorge.

Along with producing tracks on Beyoncé's Lemonade, Diplo collaborated with Canadian DJ duo Zeds Dead on the release "Blame", which featured Swedish singer Elliphant.

[29] The two received support by many already established Jamaican artists such as Vybz Kartel, Elephant Man and Ms. Thing, and the resulting record Guns Don't Kill People... Lazers Do also featured vocals from Santigold, Amanda Blank, Nina Sky, Ricky Blaze and more.

"[42] The track "Pon De Floor" from Guns Don't Kill People... Lazers Do was sampled for Beyoncé's single "Run the World (Girls)".

It features artists such as Ezra Koenig, Bruno Mars, Ward 21, Wyclef, The Partysquad, Shaggy, Tyga, Flux Pavilion and Wynter Gordon.

[50][51] Their fifth studio album, Music Is the Weapon, features collaborations with Alessia Cara, French Montana, Anitta, Khalid, Skip Marley, Marcus Mumford, J Balvin, El Alfa, Mr Eazi and Nicki Minaj.

[53] Diplo announced the project by releasing the Mad Decent Block Party lineup with Jack Ü playing at multiple stops on the tour.

They played two sold-out shows including Coachella Valley Music Festival in Indio, California and Lollapalooza in São Paulo, Brazil.

[citation needed] On January 2, 2018, Diplo announced a new project with British DJ and singer Mark Ronson, entitled Silk City.

[63] Diplo had a late night show on BBC Radio 1 / 1Xtra on Saturdays 11:00 p.m.–1:00 a.m. (GMT) called 'Diplo and Friends' where he curated mixes from some of biggest names in dance music.

[65] Beginning on October 2, 2015, Diplo, Jillionaire, Walshy Fire and Eric Hamilton debuted "Lazer Sound" on Apple Music's Beats 1.

The newest radio show, curated by Diplo, and the Major Lazer crew, consists of interviews, moments on tour and brand new music.

[citation needed] In February 2016, Diplo was one of the first and very few mainstream Western artists to perform in Islamabad, Pakistan alongside Adil Omar, Talal Qureshi, SNKM and Elliphant.

[67] In 2018 Diplo returned with Major Lazer for Islamabad's first Mad Decent Block Party alongside Adil Omar, SNKM, Talal Qureshi, Valentino Khan, Chrome Sparks, Lyari Underground and a host of other acts.

[68] In January 2017, Diplo and Autoerotique (a house group from Toronto) released a music video titled "Waist Time" which was filmed in a warehouse in London.

[69] He also sang a song "Phurrr" in Bollywood in Imtiaz Ali's film Jab Harry Met Sejal starring Shah Rukh Khan and Anushka Sharma.

[86][87] In August 2023, Diplo attended and played from a hot air balloon at the 35th Burning Man festival in Black Rock City, Nevada.

[89] In October 2020, an anonymous woman filed suit against Diplo for rape, claiming that he gave her an STD, as well as recording sexually explicit videos of her without consent.

It was alleged that in March 2019, the then 22-year-old woman was raped in a Las Vegas hotel room after privately chatting with Diplo on Twitter for approximately five years.

Diplo, in response, filed a restraining order and claimed that the anonymous woman had been harassing and stalking him for a long duration of time, and was posting nude photographs of him without permission as well.

[90] In November 2023, American rapper Azealia Banks posted an Instagram Story in which she accused Diplo of sexually coercing her during the time they worked together when she was 17 years old.

[93] Jane Doe reported the distribution of these materials to the New York Police Department on November 7, 2023, leading to an investigation and a warrant for Diplo's arrest.

Diplo's lawyer, Bryan Freedman, dismissed the allegations as part of a pattern of "bogus" lawsuits, asserting that his client had been targeted by unscrupulous individuals seeking a meritless payday.