He recorded their first two studio albums with the band, Dear Diary, My Teen Angst Has a Bodycount (2004) and Heroine (2006), before leaving to pursue a solo career in 2007.

[12] After releasing the extended play Gypsyhook (2009), Moore was scheduled to record his debut studio album, Bells, with producer Noah Shain.

[21] At the ages of 9 and 10, Moore attended a boarding school in the Mojave Desert LV[clarification needed], but eventually moved back to Northern California.

After flying out to Georgia, Moore was heard singing by three studio producers, Derrick Thomas, Eric Dale, and McHale Butler, and was then made lead singer, with Good playing guitar.

On April 7, 2007, alongside harpist Carol Robbins, Moore played several original songs at a local art building.

[31] In February 2008, Alternative Press Magazine announced the second annual AP Tour, with All Time Low, The Rocket Summer, The Matches, and Forever the Sickest Kids, as well as Sonny Moore.

The tour started in Houston, Texas on March 14 and went through North America, ending in Cleveland, Ohio on May 2, with the majority of the shows being sold out.

During this tour, Moore's line-up consisted of Sean Friday on drums, Christopher Null on guitar, and Aaron Rothe on keyboards.

He toured with Hollywood Undead in April 2009 performing under the band name "Sonny and the Blood Monkeys", with Chris Null (electric guitar), Sean Friday (drums, percussion, and beats) and Aaron Rothe (keyboards, synthesizers, programming, and turntables).

[36] Moore provided programming and vocals for UK metalcore band Bring Me the Horizon on their third studio album, There Is a Hell Believe Me I've Seen It.

[37] Later in the year, Sonny began a nationwide tour with deadmau5 after being signed to mau5trap recordings and released his second EP, Scary Monsters and Nice Sprites.

Moore kicked off the "Project Blue Book Tour" in 2011 with support from Porter Robinson, Tommy Lee and DJ Aero as well as appearances from Sofia Toufa for a new song, "Bring Out the Devil".

Skrillex unveiled several new songs on this tour including "First of the Year" (formerly known as "Equinox"), "Reptile", and "Cinema" (remix of a Benny Benassi track).

On April 18, 2011, Sony Computer Entertainment (SCEA) development studio Naughty Dog released a trailer[39] for the multiplayer component of their PlayStation 3 game Uncharted 3: Drake's Deception, featuring "Kill EVERYBODY" from Scary Monsters and Nice Sprites.

In December 2012, "Make It Bun Dem," a ReggaeEDM track featuring Damian Marley, was used in as a looped variant during the single-player mission 'Kick the Hornets Nest' in the video game Far Cry 3.

[45] In 2013, Skrillex formed a duo with Diplo called Jack Ü. Jack Ü's debut performance took place at the Mad Decent Block Party in San Diego on September 15, 2013, which is a nationwide tour that record label Mad Decent puts together to showcase artists signed to the label.

[46] Diplo announced the project by releasing the Mad Decent Block Party lineup with Jack Ü playing at multiple stops on the tour.

[51] In 2017, he released the songs "Chicken Soup" with Habstrakt, "Would You Ever" with Poo Bear, "Saint Laurent" with DJ Sliink and Wale and "Favor" with Vindata and NSTASIA.

On July 28, 2018, Skrillex collaborated with Japanese musician Yoshiki for performances of "Endless Rain" and "Scary Monsters And Nice Sprites" at Fuji Rock Festival in Niigata, Japan.

[53][54] On October 8, 2018, Skrillex uploaded a photo to Twitter showcasing a collaboration between him and English DJ and producer Joyryde, later posting a video teaser of the song to Instagram.

[57][58] On October 25, 2018, the single "Arms Around You", a collaboration between XXXTentacion and Lil Pump featuring Maluma and Swae Lee, was released; the song was produced by Skrillex alongside Mally Mall and JonFX.

[59] Skrillex, Poo Bear, and Japanese-American singer Hikaru Utada collaborated on "Face My Fears", an opening song for the video game Kingdom Hearts III.

In January 2023, Moore posted a short video to social media teasing the release of his long-anticipated follow-up to his 2014 album, Recess.

He is separately credited as "Sonny Moore" on the title track of his second 2023 album, and is featured as a vocalist for the first time since 2015's Skrillex and Diplo Present Jack Ü.

[67] On February 17, 2023, Skrillex released his second album, Quest For Fire, featuring a mix of pre-released singles and new songs, containing a range of genres with artists such as Flowdan, Porter Robinson and Fred Again credited.

Critical reception was generally positive, with Ben Jolley for NME writing that "[Skrillex's] return largely lives up to the hype" by "often channel[ing] nostalgia", yet also commenting that "the album lacks a clear narrative or overarching theme".

Moore stated in an online interview that he is a longtime fan of Warp, a label whose roster includes notable electronic artists such as Aphex Twin and Squarepusher.

[23] In a series of tweets in January 2023, Skrillex shared his struggles with mental health, revealing the reason behind the cancellation of his appearances at Movement Detroit and Tampa's Sunset Music Festival: "[I have] had the toughest year of my life in 2022, as did so many others.