In May of the following year, after touring across Europe and North and South America, the singer reissued the album with the subtitle Paw Prints Edition, including four additional songs and four remixes.

[4] Two years after Sunshine Kitty, Lo started teasing via social media the release of a fifth album; by September 2021, the record was "taking shape".

[5] Earlier that year, in April, fellow singer Charli XCX revealed she worked with Lo in "making the best music ever" in Palm Springs, California.

[6] Lo's first solo effort in almost two years and Dirt Femme's lead single, "How Long" was released on 26 January 2022 as part of the soundtrack from American television series Euphoria.

[11][12] The song's music video premiered the same day[13] and was directed by Brazilian duo Alaska Filmes, with whom Lo previously worked with on "Are U Gonna Tell Her?".

[12] On 21 June 2022, Lo officially revealed the album's title to be Dirt Femme, as well as its track listing, artwork and release date of 14 October.

[17] In the album's artwork, Lo wears a metallic, robotic scorpion stinger—a reference to her astrological sign, Scorpio—attached to her back while her vagina-inspired logo lies on the side of her hip.

The result is a body of work encompassed by songs that "will contradict each other, will probably upset some of you, will make you want to dance, cry, fuck, and drive your car really, really, fast".

[7] "2 Die 4" samples Swedish character Crazy Frog's 2005 cover of Gershon Kingsley's 1969 song "Popcorn"; it was described as a "nostalgic wet dream" by Rolling Stone's writer Tomás Mier.

[7] Lo stated that "True Romance" was recorded in a single take and was "really fun" to make due to its more "dramatic" and narrative tone in comparison to most of her works.

[7] Since its lyrics are "very dirty" and play "over a really sexy beat", Lo described "Pineapple Slice" as a mix of "Disco Tits" and "Bitches", both included of her 2017 album Blue Lips.

[21] The Line of Best Fit writer Sam Franzini poined out that "confidence and unadulterated passion for being herself comes together on Dirt Femme, a much darker album than its predecessor Sunshine Kitty, but truer to Nilsson with its pulsating beats and slinky jams" and also described the album as "sexy, smart, and most importantly; fun"[25] Emma Swann of DIY writes that Dirt Femme sees Lo juxtapose elements ingeniously.

[22] Gigwise writer Jordan White described the album as "hot-bodied" additionally stating that is "overtly camp and doesn't shy from its playful side".