DisProt is a manually curated biological database of intrinsically disordered proteins (IDPs) and regions (IDRs).

DisProt entries are annotated by professional and community biocurators from experimental data published in scientific literature.

Starting 2020, DisProt releases ‘thematic datasets’ describing biological areas where IDPs are involved in and play a crucial role.

Entries from the following organisms are accessible from the DisProt home page under the ‘Organisms’ section and can be downloaded as single files: Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomices cerevisiae, Escherichia coli, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans.

DisProt versions and releases include changes to the website and to the manually curated content of the database.