After appearing in the Chinese action comedy Kung Fu Yoga (2017), Patani featured in the films Baaghi 2 (2018), Bharat (2019), Malang (2020), Kalki 2898 AD (2024) and Kanguva (2024).

Directed by Neeraj Pandey and produced by Fox Star Studios, the film was released on 30 September 2016 and was a massive hit with an estimated collections of ₹216 crore (US$25 million).

[12] Taran Adarsh from Bollywood Hungama and Shubhra Gupta from The Indian Express both opined that Patani "sparkle" in her debut film.

Produced by Sajid Nadiadwala and directed by Ahmed Khan, Baaghi 2 was released on 30 March 2018 to mixed reviews from critics with praise for its action sequences.

Bharat received positive reviews from critics on release and grossed ₹325.58 crore in its lifetime theatrical run,[20] becoming a commercial success.

[21] She began the new decade with Mohit Suri's action thriller film Malang (2020) co-starring Aditya Roy Kapur, Anil Kapoor and Kunal Khemu.

[24] In 2021, Patani reunited with Salman Khan as the leading lady in Prabhu Deva's Radhe, which was delayed by a year due to the COVID-19 pandemic.

[26] In 2022, Patani played a retail salesgirl in Mohit Suri's psychological thriller Ek Villain Returns alongside John Abraham, Tara Sutaria and Arjun Kapoor.

[28] Sukanya Vema of Rediff wrote "Ek Villain Returns falls back on the popularity of the Galliyan track to boost its appeal".

[30][31] Pratikshya Mishra of The Quint termed Patani a "potential action star", while praising her fight sequence, but added that her dialogues fail to make an impact.

[44][45] Patani is a prominent celebrity endorser for brands and products including Joy personal care, Bata footwears and Fossil watches.

[49][50] In March 2023, Patani performed in various cities in the United States for "The Entertainers" tour, alongside Akshay Kumar, Mouni Roy, Nora Fatehi, Sonam Bajwa, Aparshakti Khurana, Stebin Ben and Zahrah S Khan.