[1] DIOS was previously known as meconium ileus equivalent, a name which highlights its similarity to the intestinal obstruction seen in newborn infants with cystic fibrosis.

[2] Signs and symptoms of DIOS include a sudden onset of crampy abdominal pain, vomiting, and a palpable mass (often in the right lower quadrant) in the abdomen.

[3] Additional diagnoses which may present with similar symptoms to DIOS include severe constipation, appendicitis, and intussusception.

[1] Differentiation of DIOS from constipation is generally performed by a unit specializing in the treatment of cystic fibrosis.

[1] Individuals prone to DIOS tend to be at risk for repeated episodes and often require maintenance therapy with pancreatic enzyme replacement, hydration and laxatives (if the symptoms are also mild).