She was a brown mare bred by Mill Park Stud & R. Dinham of South Australia and was sired by Hurricane Sky from My Madonna by Prego (IRE).
She made her debut as a two-year-old (2yo) in February 2005 at Cheltenham Park Racecourse, South Australia in a race in which she came from last on the home turn to win.
Divine Madonna had three starts in the spring for a win in the listed MRC Twilight Glow Stakes and two seconds and was then given a 13 weeks spell.
After a spell she had four starts for a win in the G1 STC Queen of the Turf Stakes, a second in the G1 Coolmore Classic, and a third in the G1 Doncaster Handicap.
Divine Madonna had six starts which included wins in the G1 MRC Toorak Handicap and G1 VRC Myer Classic over 1,600 metres.