[1] Much of Division Street is designated as highways U.S. 395 and U.S. 2 as they run northward from Interstate 90 through Spokane to destinations north of the city.

[6] Due to the critical role of Division Street as a heavily used route in Spokane,[2] discussions immediately began on how to restore connectivity between the two sides of the river.

The anticipated drop in traffic along North Division is expected to provide opportunities for the street to be transformed.

In 2020, local government and transportation planning agencies launched a two-year long study to explore potential evolutions to Division including implementing rapid transit, making the street more multi-modal to better accommodate pedestrians and bicyclists, as well as land-use zoning changes that would increase density and bring residential development to the historically low density commercial corridor.

[14] The road runs across the South Hill, northward toward Downtown Spokane, as a small, two-way residential side street.

The road picks up again on the north side of the park and continues for 6 blocks where it is interrupted by Grand Boulevard and other roadways that descend the steep, north-facing slope of the South Hill.

After 5 blocks, South Division picks up alongside Providence Sacred Heart Medical Center and Children's Hospital, continuing down the South Hill where it has an interchange with Interstate 90, passing underneath the freeway which runs as a raised viaduct through Downtown Spokane.

This intersection with Spokane Falls also provides a connection from Division to nearby SR 290 (Trent Avenue) that runs just to the east.

[13] While the entire length of North Division is flanked on both sides by commercial activity, this section of road between the vicinity of Buckeye Avenue and Garland Avenue is home to many local small businesses that draw customers from the Inland Northwest region and range from automobile shops, to Asian restaurants, jewelry stores, gardening shops, and clothing stores.

After Lincoln Road, Division encounters another hill, this time descending down about 100 feet in elevation toward its intersection with Newport Highway.

At this point, the roadway also reduces down to two travel lanes in each direction and passes by Whitworth University at Hawthorne Road.

US 395 continues into exurban and rural areas of Spokane County, eventually passing by Deer Park, Washington, on its way to the Canada–United States border.

North of Interstate 90, from Downtown Spokane onward, Division Street is characterized entirely by commercial development on both sides of the road, passing by numerous office buildings, strip malls, shopping centers (including NorthTown Mall), big-box stores, motel and hotel lodging, fast food, restaurants, auto dealerships, as well as the Spokane Convention Center.

The wide, straight streets of both Division and the Newport Highway make it attractive for illegal street racing; the Spokane Police Department, Spokane County Sheriff's office, and Washington State Patrol have conducted emphasis patrols to reduce reckless driving by groups congregating in abandoned store front parking lots then racing along its route.

[17] The section of Division Street in downtown where it intersects with West Main Avenue on the edge of the University District is one of the city's primary destinations for nightlife.

Division Street between Main and Spokane Falls Boulevard is flanked on both sides with bars and night clubs.