She subsequently featured in films including Dus (2005), Lage Raho Munna Bhai (2006), Honeymoon Travels Pvt.

[6][7][8] After her mother married Ahmed Mirza, a Muslim man from Hyderabad, she adopted her step-father's surname.

She then attended Stanley Junior College before graduating with a Bachelor of Arts from Ambedkar Open University, Hyderabad.

[10] At the same time, she modelled for print and TV commercials for brands such as Lipton, Wall's ice cream, Emami and many more.

[14] She then appeared in films such as Alag, Dum, Deewaanapan, Tumko Na Bhool Paayenge, Tumsa Nahin Dekha: A Love Story, Parineeta, Dus, Lage Raho Munna Bhai and Salaam Mumbai.

She has also produced Love Breakups Zindagi, Bobby Jasoos[16] and a sitcom web series titled Mind the Malhotras, streaming on Amazon Prime Video.

[21] Mirza has been involved with the Cancer Patients Aid Association and Spastics Society of India, and has worked extensively with the government of Andhra Pradesh to spread HIV awareness, prevention of female foeticide, PETA, CRY and most recently the NDTV Greenathon – an effort to find tangible solutions against pollution and the book, "Deke Dheko" by Radio Mirchi (a campaign initiated to collect books for underprivileged children).

[22][23] Mirza, along with Aamir Khan, publicly expressed support for the Narmada Bachao Andolan, a group protesting the building of a dam.

This aroused the ire of political activists from the Bharatiya Janata Party, who led a protest march against the actress.

Along with these, Mirza has endorsed The Body Shop for their stand on a ban on animal testing and propagation of recycled packaging and natural products.

As an ambassador, the actress would interact with school and college students from across the country through awareness sessions, community cleaning activities and motivational videos.

[40] In April 2014, Mirza became engaged to her longtime business partner Sahil Sangha, and they were married on 18 October 2014 at his farmhouse in Chhatarpur, South Delhi.

[44][45][46] On 14 July 2021, Mirza announced that she had a premature birth to a baby boy, Avyaan Azaad Rekhi on 14 May and he was in NICU for 2 months.