The film stars Mala Sinha, Biswajeet, Mehmood, Om Prakash and Neetu Singh, credited as Baby Sonia.

It is a remake of the 1965 Tamil film Kuzhandaiyum Deivamum which itself was based on the 1961 American film The Parent Trap, based on Erich Kästner's 1949 German novel Lisa and Lottie (German: Das doppelte Lottchen).

Proud, wealthy, and haughty Kiran meets down-to-earth middle-class college student, Shekhar, and after several clashes and misunderstandings, both fall in love and decide to get married.

Years later, Ganga and Jamuna meet at a school outing and both decide to switch places to get to know the other's parent.

Do Kaliyan was a major commercial success and, according to film historian Randor Guy, "further brightened the radiant image of Meiyappan and AVM Studios".