[1] The series follows Dr. Jason Cole as he balances working as a neurosurgeon with suppressing his evil alter ego, Ian Price.

Do No Harm is a modern take on Robert Louis Stevenson's classic 1886 novella Strange Case of Dr Jekyll and Mr Hyde.

On February 8, 2013, it was announced that NBC had cancelled the series after airing two episodes, due to low ratings.

[31] The series was criticized for being far-fetched and having poor writing,[32][33] although Steven Pasquale's performance as Jason Cole/Ian Price was praised.

[34][35] Mary McNamara of the Los Angeles Times described the series "not so much a thrilling psychological drama as a mismatched roommate comedy.