This cartoon's plot follows the same formula as Tree for Two (1952), except that this time it is a Dr. Jekyll and Mr. Hyde parody, as opposed to a black panther that escaped from the zoo.

Sylvester panics and runs as he is being chased by the dogs until he takes refuge inside a place named after Dr. Jerkyl and Mr. Hyde.

Out of breath, Sylvester accidentally ingests Dr. Jerkyl's formula, mistaking it for soda, which causes him to become a large and grotesque “Mr.

Alfie coaxes Sylvester to come out, only to be confronted by him in his Hyde form again, leaving him completely scratched and falling apart into pieces literally once he comes out of the room.

Relieved that the cat is gone, Alfie takes advantage of this by faking a fight to fool Chester, while throwing and smashing glass vessels.

The formula takes effect almost at once, creating a hideous fly monster who proceeds to thrash Alfie and throw him out of the place.