The group was founded in 2022 by Stanley Goldfarb, a retired kidney specialist and former associate dean of curriculum at the University of Pennsylvania Medical School, with funding from Joseph Edelman.
[6] According to the Associated Press, the group by 2023 had "evolved into a significant leader in statehouses seeking to ban gender-affirming care for transgender youths".
[2][5] According to the Associated Press, the model legislation has been criticized for "using technical medical terminology as political rhetoric to scare people".
[2] According to Columbia University's Jack Drescher, editor of the gender dysphoria section of the American Psychiatric Association's 2022 diagnostic manual update, the model legislation language is "designed to inflame".
[1][7][8] On December 4, 2024, Do No Harm organized a rally to oppose gender-affirming care for minors outside the Supreme Court of the United States during the oral arguments for United States v. Skrmetti, which will determine whether bans on gender-affirming care for minors are constitutional.