He was a pivotal figure in the historical preservation of New Orleans jazz in the middle of the 20th century.
Souchon received schooling to become a physician in Chicago, though he was playing regularly in groups such as the Six and Seven Eighths Band in the 1910s.
Alongside this, Souchon recorded with many noted New Orleans jazz mainstays, such as Johnny Wiggs, Sherwood Mangiapane, Papa Jack Laine, Raymond Burke, and Paul Barbarin.
He had his own radio program on WWL, and edited the journal Second Line from 1951 until his death in 1968.
His record collection, which included some 2,000 recordings of New Orleans jazz, was bequeathed to the New Orleans Public Library, and many other music-related materials he collected are now in the possession of the William Ransom Hogan Jazz Archive at Tulane University.