[1] The series is based on a novel by Piyaporn Wayuparp, and the cast includes Nadech Kugimiya, Kimberley Anne Woltemas, Purita Suphinchumphu and Alex Rendell along with Nipaporn Thitithanakarn, Wisarut Hiranbut, Nopphawit Thaitae, Sanya Kunakorn, Songsit Roongnophakunsri, Kwanruedee Klomklom, Polwat Manuprasert, Sarut Wichitranond and Niti Chaichitathorn.

[2] Doctor Detective made a fitting for the cast's clothes on Thursday, March 24, 2022,[3][4] with Nithiwat Cholvanichsiri as the director of the drama.

Phiyada Jutharattanakul, the producer of the drama, said that it was based on the current epidemic situation.

[4] Until Monday, October 10, 2022, the first teaser trailer for Doctor Detective was released along with other dramas.

[6] Then, on Thursday, July 27, 2023, a sacrifice ceremony was held for the drama "Doctor Detective" officially at Channel 3 studio, Nong Khaem.