One episode, "Long Day's Journey Into Deirdre", remains unaired in the United States (although it was aired as part of series runs in Australia and Great Britain).
Though at first serving as "straight men" for Frewer's manic style of comic acting, the other characters gained more depth as the series progressed, and the plots sometimes focused on issues such as AIDS, breast cancer, and homophobia.
His many responsibilities sometimes plays havoc with his love life, as is exemplified in the pilot episode where his unhappy girlfriend has to resort to making a doctor's appointment to see him.
Carry III): Mike's best friend and medical partner, an uptight, ambitious African-American who is anxious to have the “perfect life,” leading him to become at times overly controlling with his wife and son.
Deirdre Bennett (Maureen Mueller): The medical partner who comes off as aloof, or as she puts it, “a complete bitch,” and is not above exploiting a situation for her own benefit.
Leona Linowitz (Anne Ramsay): Psychiatrist and Grant's sister, Leona appears in the final season when she moves to Rhode Island with her daughter after her ex-husband writes a hit play which features a character based on her known only as "The Domineering Bitch" Elizabeth McQueen (Jane Brucker): Mike's sometime girlfriend, and television producer of "Wake Up Providence," Elizabeth tries to keep the show together as Mike presents one wacky medical segment after another.
The music for the opening titles was the rock and roll song "Good Lovin'", written by Ahmet Ertegün, Leroy Kirkland, Jesse Stone, and Danny Taylor.
The conflicts increased as he started a promotional campaign for his first novel, Panacea, and began doing medical segments for the local morning news show Wake Up, Providence.
Though Mike tries to cover serious medical issues in his segments on "Wake Up Providence," they usually devolve into unplanned lunacy, which only endears him more to his viewers, and even raises the show's ratings, much to Hugh's dismay.
After Elizabeth's departure from the show, Mike finds himself fending off requests to do "disease of the week" pieces, or even to promote products such as a "Miracle Slimming Supplement".