The fifth and final[1] season of Doctor Doctor (known internationally as The Heart Guy), an Australian drama television series, premiered on Nine Network on 28 April 2021.

[3] Season five will feature several new cast additions; including Zoe Ventoura, Lincoln Younes, Darren McMullen, John Waters, Chantelle Jamieson, Rishikesh Shukre and Contessa Treffone.

[4][5][2] The town of Whyhope is in crisis; with the recent bushfires and the COVID-19 pandemic, things are set to escalate.

Hugh has decided the time has come to return to Sydney and resume his career as a heart surgeon, that is until a number of complications begin to surface, bringing his plans to a halt.

[15] Filming commenced on 28 September 2020,[16][17] where social distancing requirements had been put in place.