Published in 1936, it is chronologically the first novel in the series, followed by Doctor Syn Returns, though it was the fourth in terms of publication.
The novel was anticipated by Thorndike's fans, according to The Liverpool Echo, which praised it as a "salt breath of Channel air".
Comprising half of a ten-part series titled Doctor Syn, it was read by Rufus Sewell.
[4] Peter Cushing, in preparation for his role in the 1962 film Captain Clegg, read several Thorndike novels, including Doctor Syn on the High Seas.
The novel's description of Syn's hair turning white inspired Cushing's on-screen appearance.