[2] Writers for the Doctor at Large episodes were Bill Oddie, Graeme Garden, John Cleese, Graham Chapman, Bernard McKenna, Geoff Rowley, Andy Baker, Jonathan Lynn and David Yallop, as well as George Layton (under the pseudonym of "Oliver Fry").

[3][4][5][6] The plot revolves around newly qualified Doctor Michael Upton as he tries to make a start in his profession.

He obtains a series of jobs, including working in otolaryngology and as a general practitioner, before returning to St. Swithin's Hospital (where he received his training) as a Junior Registrar.

Notable events also include Upton's (and other young doctors') pursuit of women.

The first six episodes, from "Now, Dr. Upton" to "Congratulations, It's A Toad", were recorded in black and white due to the ITV 'Colour Strike'.