Dodo von Knyphausen (1641–1698) was a German nobleman from the Duchy of Prussia in the service of Brandenburg-Prussia during the reigns of Electors Frederick William and Frederick III.
In 1689 Knyphausen organized the creation of the efficient Geheime Hofkammer, or collegiate central control office, for Brandenburg-Prussia.
After Brandenburg-Prussia received little from the 1697 Peace of Ryswick that ended the Nine Years' War between France and the Grand Alliance, Knyphausen and Eberhard von Danckelmann were sacked as scapegoats.
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