The brewery was featured prominently in the documentary Beer Wars and was the subject of the Discovery Channel series Brew Masters, which premiered Sunday, November 21, 2010.

[8] Sam Calagione started brewing in his kitchen in New York City,[9] where he created his first beer out of overripe cherries with his roommates Ken Marino and Joe Lo Truglio.

[18] Pangaea, first released in 2003, is a Belgian-style strong pale ale made with ingredients from every continent on Earth, including: crystallized ginger from Australia, water from Antarctica, basmati rice from Asia, muscavado sugar from Africa, quinoa from South America, European yeast, and North American maize.

[citation needed] The New York Times in 2010 profiled the brewery's efforts to make chicha beer, a traditional Latin American beverage made from maize, which requires chewing the corn and spitting it in a communal pot.

[citation needed] In the late 90s, Dogfish Head started an "Ancient Ales" series, in which beer recipes were created based upon the chemical analysis of residue found on pottery and drinking vessels from various archaeological sites.

The recipe for this beverage is based on the chemical analysis of residues found in clay vessels believed to date back to the 8th century BC.

In 1997, molecular archeologist Dr. Patrick McGovern received a phone call from a former student of his informing him of a residue on clay jars from the tomb of King Midas.

Dr. McGovern quickly did chemical analysis finding all aspects of the drink except for the spicing agent but made an assumption of saffron due to regional availability.

[27] The ingredients for the original 7.5% ABV recipe in 2001 included yellow muscat grapes, lightly toasted 2-row barley malt, thyme, honey and saffron.

[29] In 2010, Calagione collaborated with Washington winemaker Jarrod Boyle of Alexandria Nicole Cellars to produce a "hybrid" beer-wine beverage labeled Noble rot.

A saison-style beer, the brewery uses botrytis-infected Viognier and Pinot gris grapes from Alexandria Nicole's Destiny Ridge Vineyard in the Horse Heaven Hills AVA in the brew.

Alexandria Nicole presses the grapes, leaving the skins with the must, and Dogfish co-ferments the Viognier and grains while adding the Pinot gris later in the process.

Traditional sahti is brewed with a variety of grains, malted and unmalted, including barley, rye, wheat, and oats; then flavored with juniper berries in addition to, or instead of, hops.

Dogfish Head has worked with the Grateful Dead to create a strong pale ale called American Beauty, a pickle company in Brooklyn, NY called Brooklyn Brine to create a pickle with beer ingredients, and an old glass company in Europe to design a unique IPA glass.

[citation needed] Dogfish Head will be one of the main partners in Birreria, the roof-top brewpub being constructed at Mario Batali's Eataly project in New York City.

The series premiered on Sunday, November 21, 2010 with an episode focusing on the creation of the Bitches Brew beer to commemorate the Miles Davis album of the same name.

[citation needed] Dogfish Head's Brewings & Eats restaurant was featured in a December 2021 episode of the Cooking Channel's Man v.