It was bred in the early twentieth century in Córdoba in central Argentina, primarily for hunting large game such as peccaries, wild boar, and pumas.

[7]: 21  Nores Martinez later introduced crosses with a variety of other dogs including the Irish Wolfhound, Boxer, Great Dane, Bull Terrier, Dogue de Bordeaux, and Spanish Mastiff.

[7]: 28  Antonio Nores Martinez was murdered in 1956; however Augustin, now an international ambassador, would continue to promote the Dogo during his travels.

[1][10] Like many other breeds, the Dogo has some genetic predisposition to congenital deafness; it is also predisposed to laryngeal paralysis/polyneuropathy complex.

[2]: 84 The Dogo is kept principally for hunting large game such as peccaries, wild boar, and pumas.