Amy Acker, whom Joss Whedon had intended to be a prominent component of the season, only appeared in three episodes due to the budget cut and her commitment to the short lived series, Happy Town.

[13] Joss Whedon, creator of the show, states on his audio commentary for "Vows" that shooting went so much faster than usual, due in part to the use of HD cameras and hand held direction, that his line producer, Kelly Manners, would often be; "scrambling for something to do.

[12] Whedon had originally intended to film scenes of the apocalyptic future from "Epitaph One" throughout the season but under the opinion of both the studio and network decided to drop the idea—instead having the series finale be entirely set in said storyline.

[15] The remaining three episodes aired in January with the series finale held back a week due to the Hope for Haiti charity telethon.

Michelle Fazekas and Tara Butters joined as consulting producers, replacing Elizabeth Craft and Sarah Fain, and wrote the second and penultimate episodes of the show; "Instinct" and "The Hollow Men".

Other directors included Marita Grabiak, Jonathan Frakes, Wendey Stanzler, David Straiton, Felix Alcalá, Terrence O'Hara and Dwight Little.