[3] In 1927 his father died from the after-effects of an operation and Domenico assumed the responsibility of the company together with his mother and younger brother Vincenzo.

In that year Meccanica Verghera was founded, in order to mass-produce a light-weight motorcycle equipped with a 98 cc two-stroke engine,[4] which had been designed in 1943, but development and production had been interrupted by the war.

[2] The MV Agusta models grew in popularity, and under the direct guidance of Domenico, the company developed competition motorcycles that won races and championships.

[12] On 29 January 1971, while he was accompanying the President of Finland, Urho Kekkonen, on a visit the Agusta plant, he suffered a heart attack:[13] he died four days later, in his Milan apartment in Piazza Sant'Erasmo.

[14] He was the brother of Mario Agusta, president of the Federazione Italiana Motonautica (Italian Powerboating Federation).