He was CEO of Consip, a public stock company owned by the Italian Ministry of Economy and Finance operating in the public procurement services field[2][3] and Techno Sky,[4] the ENAV Group society for maintenance and development of the air traffic management technologies.

Ever since his early youth Casalino was directly involved in social activity and in the State: first as a volunteer of the Red Cross (1977); then as an officer in the 78th Battalion "Lupi di Toscana" (1982).

He began his professional career at the Treasury Department of the Italian Ministry of Economy and Finance, where from 1988 until 2006 joined progressively increasing responsibility and duties.

[6] From 2007 to 2011, he was in ENAV – National Society of Air Navigation Services, where he was appointed head of ICT internal systems and participates in the start-up of priority projects, including 'Single European Sky', initiative of the European Commission focused on reforming the architecture of air traffic management system to meet future capacity and safety needs.

The appointment sealed a professional career has always focused on new technologies, of which the National central purchasing – at whose creation Casalino participates from the earliest moments – is an example of Italian excellence also at international level.

[18] In 2014 he was member of the Advisory Committee of the MENA-OECD Governance Programme Training Center of Caserta, together with the Ministers of Public Administration of Italy, Egypt, Jordan, Morocco and Libya.