Despite a lack of documentary sources that can shed light on the early career of Domenico, it is assumed that the young artist travelled with his elder brother in the early 1680s to Turin where they worked during the years 1684-85 on frescoes for the Monastery of Casanova at Carmagnola, a small town near Turin.
During this period Domenico also executed some canvases with biblical subjects, which are not documented, but have been attributed to him on stylistic grounds such as the ’’Susanna and the Elders’’ now in the Louvre.
From the early years of the new century Domenico commenced a period of intense independent activity in Turin, certainly after his brother's death in 1709.
He garnered greater professional recognition, which earned him commissions over a period of about twenty years in the Palazzo Madama, Turin.
Along many other artists, Domenico participated in the renovation of the building which the duchess wanted to turn into a sumptuous royal palace.
Domenico Guidobono was active in Turin and the rest of the Duchy until the ascent of the architect Filippo Juvara, who as a principal designer of the Palazzo Madama marginalized him.
Their work displays a meticulous approach to depicting the details of flowers, fruits, birds, animals, objects.
The brothers played an important role in introducing to Turin the light and festive decorative style typical of Genoese residences.