Domenico Pisani was a Venetian nobleman and briefly the lord of the Aegean island of Santorini in 1479–1480.
The festivities for the wedding at Milos and on Santorini itself were extravagant and lasted for an entire month.
As the duke had died without a son, this should have secured Pisani's possession of Santorini, but the new duke, Giacomo's brother Giovanni III Crispo—due to Salic Law, Pisani's wife could not inherit the duchy—landed on Santorini and occupied the island.
[3][6] Pisani and his wife turned to Venice for aid, but Giovanni III and his soldiers managed to repel a Venetian fleet attacking Skaros, the chief fortress of Santorini.
[7] In the end, after a complicated legal battle, the Venetian Senate resolved on 4 October 1486 that Santorini was to remain with Crispo, after paying compensation to the Pisani.