[12] Pozzovivo has a degree in economics and wrote a thesis entitled "Southern politics from the unity of Italy up to the present day".

[16] He notably took the second position on the fifteenth stage,[17] a mountain affair finishing atop the Category 1 Passo Fedaia, which was featured for the first time in Giro history.

[21] The 2010 season saw Pozzovivo take a great stage victory in the Giro del Trentino, where he edged a surging from behind Riccardo Riccò of Ceramica Flaminia by 3 seconds.

[23] Pozzovivo came in second place of the 2.1 categorized Giro dell'Appennino, where he attacked on the daunting Passo della Bocchetta, with only Robert Kišerlovski being able to follow him and crest the climb with him.

[25] He prevailed in the overall classification of the five stage race by a margin of one minute and fifty seconds over Team Sky's Morris Possoni.

He was victorious in stage 3 of that race, which led the riders from Pergine to Brenzone sul Garda, finishing after a steep climb, the Punta Veleno.

[28] Later that year, he sailed to victory in stage 8 of the Giro d'Italia, attacking on the slopes of the Colle Molella, 7 kilometres (4.3 mi) away from the finish.

His nearest pursuant, Spaniard Beñat Intxausti of Movistar Team, completed the stage with a 23 seconds deficit on Pozzovivo.

In June, Pozzovivo prevailed in the queen stage of the 2.1 rated Tour of Slovenia, a 219 kilometres (136 mi) course peppered with climbs.

Nairo Quintana (Movistar Team) resisted in his wheel to place an attack of his own, which would prove to be the decisive move as the Colombian sailed to victory.

[33] For the 2013 season, Pozzovivo left Colnago–CSF Bardiani, where he started his professional career back in 2005, and moved to World Tour outfit Ag2r–La Mondiale.

[3] He was looking to repeat his 2012 win in the Giro del Trentino, but he had to withdraw after a crash in stage 3 of the race where he injured his elbow and broke two ribs.

[38] Pozzovivo started the Giro well, avoiding any crashes during the wet opening week and attacking on Stage 9 to Sestola, where he finished third on the day behind the breakaway, taking 30 seconds from his rivals and moving into 4th in the General Classification.

[39] He also attacked successfully on Stage 14 to Oropa, but fell ill with Bronchitis on the next day, a mountain top finish at Montecampione, losing time to nearly all his rivals.

[42] Pozzovivo said in an interview that he was able to bicycle before he was able to walk on his way to recovery and that he sent his team an e-mail to the effect that he was ready to come back sooner than expected, at the Il Lombardia race.

He was part of a group of seven favorites and he attacked two kilometers from the finish line to win solo on the flat finale, after the race went over several climbs.

Shortly afterwards, AG2R reported that he was in a stable state, even though he appeared to be bleeding heavily from his head region on television pictures.

"[54] Pozzovivo did return at the Tour de Suisse and registered second place on the queen stage of the race, a 237.3 km (147.5 mi) affair which finished at the foot of the Rettenbach glacier.

[63] For 2020, Pozzovivo signed for NTT Pro Cycling,[64] and began his season in February with the Tour de la Provence.

[69] He recovered to ride to sixth place in the Tour de Suisse,[70] and was as high as third at the Vuelta a Burgos but was forced to withdraw with a fractured knee.