Domenico Purificato (14 March 1915 – 6 November 1984) was an Italian painter, mostly associated with neo-realism.

His work was part of the painting event in the art competition at the 1948 Summer Olympics.

From 1940 to 1943 he worked as an editor for the magazine Cinema, where he contributed a series of twelve essays on the relationship between painting and film.

In 1953 he is one of the artists involved with the first exhibition organized by the Federazione Nazionale Artisti di Roma, with artists such as Eliano Fantuzzi, Renato Guttuso, Carlo Levi, Vito Apuleio, Giuseppe Canizzaro, Nino Chillemi, Gino Franchina, Pietro Cascella, Antonietta Raphael, Antonio Sanfilippo, Joseph Strachota, Mario Mafai and others.

In 1956 he worked as production and costume designer for Giuseppe De Santis's film Giorni d'amore.