Domenico Sorrentino (born 16 May 1948) is an Italian Catholic prelate and the current Bishop of Assisi-Nocera Umbra-Gualdo Tadino since his appointment in 2005.

He undertook the usual seminary studies and was ordained a Catholic priest for the Diocese of Nola on 24 June 1972, having studied at the Roman ecclesiastical universities as a pupil of the Almo Collegio Capranica, an ancient Roman seminary named after Cardinal Domenico Capranica.

Sorrentino's activities as a speechwriter in the Secretariat of State brought him into contact with Stanisław Dziwisz, principal private secretary to Pope John Paul II.

He was appointed on 17 February 2001 to the rank of archbishop and the post of Prelate of Pompeii, in effect a small diocese centred on a large and popular shrine of the Virgin in the modern township of Pompei, adjacent to the ruins of the Roman town buried in ancient times by volcanic eruption.

Here Sorrentino set about plans for the rearrangement of the area surrounding the shrine, the provision of road access, and the like.