He had a workshop in the Via delle Terme, Florence, which he shared with Domenico di Zanobi (formerly known as the Master of the Johnson Nativity).
[1] His earliest extant work is a processional banner for the Ospedale degli Innocenti, Florence, in which the Virgin is shown protecting the martyred innocents beneath her mantle.
[2] In 1449-50 Domenico painted the chapel of Saint Leonard in the church of Santa Maria a Peretola on the outskirts of Florence.
Other, undated altarpieces are in Anghiari (Santo Stefano), Dijon (Musée des Beaux-Arts),[5] Florence (Galleria dell'Accademia), San Gimignano (Museo Civico) and San Giovanni Valdarno (Museo della Basilica di Santa Maria delle Grazie).
It has been suggested that the painting was inspired by Giovanni di Paolo's illumination for Paradiso 17 in the celebrated Yates Thompson Manuscript (c. 1444-1450; London, British Library, Yates Thompson MS 36), one of the finest Divine Comedy manuscripts ever produced, which shows all of the same details but in reverse.