[4] Her first feature film, Thursday Till Sunday (De jueves a domingo) was developed as part of the program La Résidence by Cinéfondation / Festival de Cannes, and premiered at International Film Festival Rotterdam, where it was awarded the Hivos Tiger Award.

[7][8] Her next feature Too late to die young (Tarde para morir joven), premiered at Locarno Film Festival and brought her the Leopard for Best Direction.

[9][6][10] She was one of the seven directors of the feature film The year of the everlasting storm, alongside Jafar Panahi, Anthony Chen, Malik Vitthal, Laura Poitras, David Lowery and Apichatpong Weerasethakul.

[13][14][15] Over the past decade Dominga has also taught film courses and gave talks in Chile and abroad and made videos and photographs for exhibitions, like "Little Sun" (Olafur Eliasson, 2012) at the Tate Modern in London.

With Omar Zuñiga she co-founded Cinestacion production company, her credits as a producer include Felipe Galvez's Chilean Western The Settlers, Manuela Martelli's directorial feature debut 1976,[20] and The Last Land by Paraguayan Pablo Lamar.