In 2022, Fike became a cast member of the second season of Euphoria, in his first main acting role, playing Elliot, a drug-abusing teenager.

[2] In 2023, Fike released his second studio album, Sunburn, preceded by singles "Dancing in the Courthouse", "Ant Pile", "Mona Lisa" (a track which is featured in the 2023 superhero movie Spider-Man: Across the Spider-Verse), and "Mama's Boy".

[7] His mother had persistent problems with drug addiction and spent much of Fike's childhood in and out of jail, causing him to stay in different homes, such as those of his older brother, distant relatives or his parents' friends.

He first acquired a guitar at the age of ten and learned how to play songs by the Red Hot Chili Peppers.

[11] Later they coalesced into a formal rap collective which attracted an audience in the community and Fike formed a sub-group called Lame Boys ENT.

[13][8] Fike first gained recognition by making beats with his then producer, Hunter Pfeiffer (known as 54) leading to several popular songs on SoundCloud being published.

He released the EP Don't Forget About Me, Demos at the age of 22 in October 2018 as a signed artist, which was recorded while he was on house arrest for battery of a police officer.

The single gained wide attention and peaked within the top ten of the charts in Australia, Ireland, and the United Kingdom.

[11][15] It was placed on rotation on several radio stations and Spotify playlists, and received favorable reviews from outlets such as Rolling Stone, Pitchfork and Billboard.

[19] On April 4, 2019, Brockhampton uploaded a video to their YouTube channel called "This Is Dominic Fike" which featured his single "3 Nights" in it.

Reaching over 4 million views with their biggest hit being a song called "Peach" off Kevin Abstract's Arizona Baby album.

[25] On the fifth day of that month, he performed a song that was unreleased at the time, "Chicken Tenders", at a Chicago concert during his Rain or Shine tour.

[30] On March 19, 2021, Fike was featured on Justin Bieber's song titled "Die for You" from the latter's sixth studio album, Justice.

[35] On May 30, 2023, Fike announced the "Don't Stare At The Sun" North America tour, with the starting date on July 13, 2023, in Indianapolis.

On July 5, 2023, Fike further announced that the tour would continue in the UK, playing in Glasgow, Manchester, Birmingham and London.

On April 24th 2024, Fike shared his new EP, titled 14 Minutes, to an exclusive group of fans in Los Angeles, California.