Dominic Ignatius Ekandem listenⓘ (1917 – 24 November 1995) was a Nigerian Catholic Cardinal who served as Archbishop of Abuja from 1989 until 1992.

He was the first native West African Catholic Cardinal in history.

A native of Akwa Ibom State, Ekandem attended several Catholic seminaries before he became a priest.

He was Bishop of Ikot Ekpene from 1963 to 1981; during that tenure, in April 1976, he was named a cardinal.

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