The Diocese of Ikot Ekpene (Latin: Ikotekpenen(sis)) is a Latin Church ecclesiastical territory or diocese of the Catholic Church.

Its episcopal see is Ikot Ekpene, Akwa Ibom State.

The Diocese of Ikot Ekpene is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Calabar.

The diocesan cathedral is Saint Anne Cathedral in Ikot Ekpene.

Deanery in the Diocese Abak Urua Akpan Ukana Ifuho Nto Edino Ika Inen