One of the oldest established schools in Zimbabwe, Dominican Convent was founded in 1892 by Mother Patrick Cosgrave, an Irish nun, with 10 pupils.

There is a museum commemorating her in the grounds of the Mukwati Building on Fourth Street in Harare, in what was the original hospital's mortuary.

In Form 3, the girls write a national paper called ZIMSEC for Shona and history (both being optional) and English language, which is compulsory.

The Sixth Form has three streams: Business Administration, which focuses on tourism and secretary courses, Arts and Sciences.

[citation needed] In 2010, the Lower Six Management of Business company, Lynx, came first in the national Junior Achievement competition.