She is known for her roles in the films May Fools (1990), Indochine (1992), La Reine Margot (1994), Those Who Love Me Can Take the Train (1998), and The Other One (2008).

In a career spanning nearly four decades, Blanc has won four César Awards from nine nominations.

In 1980, at the suggestion of Pierre Romans in whose class she was, Patrice Chéreau went to see her[1] and engaged her for a performance of Henrik Ibsen's Peer Gynt.

One of the most critically acclaimed French actresses, Blanc has won four César Awards.

One for Best Actress in 2000 for Stand-by [fr] and three for Best Actress in a Supporting Role: in 1990 for May Fools (Milou en mai), in 1992 for Indochine and in 1998 for Those Who Love Me Can Take the Train (Ceux qui m'aiment prendront le train) and has been nominated four more times.