Dominique Zeigler (born October 11, 1984) is a former American football wide receiver.

Zeigler was originally signed by the Niners on May 3, 2007; waived on August 26; then re-signed to the practice squad on September 2, where he spent the entire season.

On November 8, he was signed to the active roster and subsequently played in eight regular season games, making five catches for 97 yards and no touchdowns.

Zeigler played in 11 regular season games, making nine catches for 98 yards and no touchdowns before being placed on season-ending injured reserve on November 30 due to a torn anterior cruciate ligament in his left knee.

[3] The injury was sustained the night before during the Niners' 27-6 road win against the Arizona Cardinals.