Zenofilus held the rank of vir clarissimus, and thus was probably born into an aristocratic and senatorial family, but the commonness of his hereditary nomen, "Domitius", makes it difficult to ascertain his lineage.
[5] Zenophilus then appears to have served as proconsular governor of Achaia, no later than 323–324,[7] and in this capacity may have been involved in the Emperor Constantine's preparations of war against his rival Licinius.
Novak concluded that Zenofilus's career demonstrates "he was clearly one of the Constantinian government's most ubiquitous servants and supporters".
[10] An inscription on a seat in the Colosseum, from the time of Odoacer, names one (...)enofilus, clarissimus vir.
If the correct name is Zenofilus, then the individual could have been a descendant of the consul, though Martindale also notes the restoration 'Menofilus' is possible.