Domodossola (Italian: [ˌdɔmoˈdɔssola];[3] Lombard: Dòmm) is a city and comune (municipality) in the Province of Verbano-Cusio-Ossola, in the region of Piedmont, northern Italy.

The city is located at the foot of the Italian Alps and acts as a minor passenger-rail hub.

During World War II Domodossola was part of an uprising against the Germans, whereby the valley of Ossola declared itself a free partisan republic in September 1944 and broke away from Fascist Italy.

The rebellion was crushed by German troops within less than two months but was an important symbol for anti-fascist movements within Italy until the end of the war.

Domodossola is most famous for the Sacro Monte Calvario, a site of pilgrimage and worship close to it that has been also recognized as a humanity heritage by UNESCO.