Don Bosco Technical College (DBTC) in Mandaluyong is a pioneer of Salesian Schools in Metro Manila.

DBTC also temporarily transferred some of their primary level faculty to Don Bosco School Manila.

The Salesian Sisters Administration of DBS Manila and the Salesian Fathers Administration of DBTC Mandaluyong worked in close supervision and collaboration until April 1993 when the last group of transferees had finished their Grade 4 and enrolled back at DBTC to finish their Intermediate and High school.

Faculty members who were temporarily transferred to DBS Manila were offered a choice as to their preferred employer.

However, this agreement did not hinder the administration of DBS to start its own co-educational pre-school and grade school levels and to employ directly its new faculty and staff in 1989.

The results of the consultation showed that majority of prefer to send their in DBS until they finish their secondary school.

The Senior High School department formally opened in June 2016 with its 1st batch of 42 students enrolled under the three academic tracks; Humanities and Social Sciences (HUMSS), Accountancy, Business and Marketing (ABM), Science, Technology and Engineering and Math (STEM).

On May 24, 2019, Don Bosco School Manila was officially accredited by the PAASCU after the approval of its application in 2017.

During the Enhanced Community Quarantine in the Philippines, Don Bosco School resorted to online distance education from 2020 until mid 2023.